Thymic Origin of Intestinal T Cells Revealed by Fate Mapping of ROR t Cells
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593 (1990). 8. A. Larsson, B. M. Sjoberg, EMBO J. 5, 2037 (1986). 9. M. Högbom et al., Proc. Natl. Acad. Sci. U.S.A. 100, 3209 (2003). 10. A. Jordan, P. Reichard, Annu. Rev. Biochem. 67, 71 (1998). 11. S. Pötsch et al., J. Biol. Chem. 274, 17696 (1999). 12. M. A. Henriksen, B. S. Cooperman, J. S. Salem, L. S. Li, H. Rubin, J. Am. Chem. Soc. 116, 9773 (1994). 13. G. McClarty, G. Tipples, J. Bacteriol. 173, 4922 (1991). 14. G. Tipples, G. McClarty, Mol. Microbiol. 8, 1105 (1993). 15. C. Roshick, E. R. Iliffe-Lee, G. McClarty, J. Biol. Chem. 275, 38111 (2000). 16. Materials and methods are available as supporting material on Science Online. 17. M. Merkx et al., Angew. Chem. Int. Ed. Engl. 40, 2782 (2001). 18. J. M. Bollinger et al., Science 253, 292 (1991). 19. B. E. Sturgeon et al., J. Am. Chem. Soc. 118, 7551 (1996). 20. D. Yun et al., Biochemistry 41, 981 (2002). 21. J. Baldwin et al., J. Am. Chem. Soc. 122, 12195 (2000). 22. J. M. Bollinger et al., J. Am. Chem. Soc. 116, 8024 (1994). 23. D. Burdi et al., J. Am. Chem. Soc. 120, 12910 (1998). 24. P. J. Riggs-Gelasco et al., J. Am. Chem. Soc. 120, 849 (1998). 25. M. Fontecave, R. Eliasson, P. Reichard, J. Biol. Chem. 262, 12325 (1987). 26. G. Tipples, G. McClarty, J. Bacteriol. 173, 4932 (1991). 27. E. Elleingand et al., Eur. J. Biochem. 258, 485 (1998). 28. O. Guittet, B. Roy, M. Lepoivre, Cell. Mol. Life Sci. 55, 1054 (1999). 29. M. Fontecave, Cell. Mol. Life Sci. 54, 684 (1998). 30. J. MacMicking, Q. W. Xie, C. Nathan, Annu. Rev. Immunol. 15, 323 (1997). 31. J. U. Igietseme et al., Infect. Immun. 66, 1282 (1998). 32. L. L. Perry, K. Feilzer, H. D. Caldwell, Infect. Immun. 66, 1265 (1998). 33. K. H. Ramsey et al., Infect. Immun. 66, 835 (1998). 34. M. Horn et al. Science 304, 728 (2004). 35. This work was supported by the Swedish Research Council and the European Union–Training and Mobility of Researchers iron-oxygen network. We thank Y. Cerenius for assistance at the I711 beam-line at MAX-Lab.
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تاریخ انتشار 2004